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pentobarbital will reduce the level or impact of pazopanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.

Dosages of barbiturates should be individualized with total familiarity with their distinct properties and advised charge of administration.

pentobarbital will lower the extent or result of bazedoxifene/conjugated estrogens by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

pentobarbital will lessen the extent or result of pantoprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.

pentobarbital will reduce the extent or impact of sunitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

Barbiturates are substituted pyrimidine derivatives in which The fundamental composition typical to those drugs is barbituric acid, a compound which has no central nervous technique (CNS) exercise. CNS activity is received by substituting alkyl, alkenyl, or aryl teams around the pyrimidine ring.

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pentobarbital will decrease the level or outcome of ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers may well lower partiaprevir and ritonavir stages, and for that reason decreased efficacy of Viekira Pak

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Phenobarbital sodium is carcinogenic in mice and rats just after lifetime administration. In mice, it developed benign and malignant liver mobile tumors. In rats, benign liver cell tumors more info had been noticed pretty late in life.

pentobarbital will lower the level or impact of duvelisib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration with a robust CYP3A inducer decreases duvelisib spot under the curve (AUC), which can lower duvelisib efficacy.

pentobarbital raises effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Warning/Check. Coadministration of ifosfamide with CYP2B6 inducers may well increase metabolism of ifosfamide to its metabolite. Keep an eye on for amplified effects/toxicities if combined with CYP2B6 inducers.

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pentobarbital will lower the level or influence of dapsone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known.